Makes me think of the pilot episode of failed TV series "The Event":

http://en.wikipedia.org/wiki/The_Event

Sean Walker (Jason Ritter) unwittingly becomes involved in a mysterious conspiracy after his girlfriend Leila (Sarah Roemer) is abducted while they are on a cruise ship. Meanwhile, the US President Martinez (Blair Underwood) plans to shut down a top-secret detention center, Mount Inostranka, in Alaska and reveal a cover-up directly tied to its detainees and their mysterious leader, Sophia (Laura Innes), despite the objections of the Director of National Intelligence Blake Sterling (Željko Ivanek). Sean boards a plane and pleads with the pilot, Leila's father Michael (Scott Patterson), not to crash it into the President's press conference in Miami. As the plane approaches the press conference site, it flies into a vortex in mid-air and vanishes.
The show was actually pretty good, but it started off with some weak/confusing episodes, and people gave up on it by the time it had improved.

Actually, as already brought up, I guess this reminds people more of "LOST".

To me, everything points to a massive bomb destroying the plane, aside from the plane attempting to turn around. Perhaps the turning around can be attributed to the terrorists first demanding the pilots doing so, and then the bomb went off anyway (either accidentally or because people tried to fight them).