When drugs were declared public enemy number one by Nixon in 1971 opioids killed 1,5 out of 100k Americans. Now that number is about 18 out of 100k. That's success for you.

On most years you can double or triple that number if you consider all deaths cause by the drug trade related to US. Double if all you care are Americans and triple if you care about people outside US. Few years ago Sinaloa Cartel provided 80% of all Fentanyl in the US.