The guy playing as icfishies isn't John Stamos, and it's not the real icfishies, either.

But anyway, yes, with experience you can learn to save bets on the turn and river by folding, but you have to be careful when doing so in heads-up pots.

One good thing to do is watch how your opponent plays his rivers. If you see him make a fair amount of bluff river bets and super-thin value bets, it's hard to make tight river folds against him. However, if he tends to check behind on the river with no hand (if you've called his betting the whole way), then you can respect his river bets more. A lot of players assume that their opponents will call the river with any pair or any ace high, so they often won't throw that final bet in if their draw didn't get there.

Against bad players, you really can't make tight laydowns ever, unless the player's leak is super-straightforwardness and lack of ability to bluff.

Also, never get into heads-up raising wars with a hand that has no showdown value, unless you are a favorite to get there.

For example, let's say you have 7d9d and the board is KdQd3c. Don't bother being super-aggro on a board like that against 1 opponent, because he probably hit a piece of that flop if he's giving you action, and he knows there's a good chance you have a draw, so he's also calling down ace high and lower pairs. You're better off playing this one passively until you get there, because your 9-high will almost never win on its own.

It's a lot more justified to be aggressive with AsJs on a board of 8s6s2c because you might already have the best hand, and you also probably have outs to your overcards, too.

You can also be aggressive with the 7d9d on a flop like 6d8s2d because you are a favorite to get there with either your straight or flush draw, and being aggressive on the flop will disguise your hand if you do make one of them (especially the straight).